Little Lab PDF's
2011
Little, TJ, Allen, JE, Babayan, SA, Matthews, KR, & N. Colegrave (In Press) Harnessing evolutionary biology to combat infectious disease. Nature Medicine (PDF coming soon)
Stjernman, M and T.J Little. (In press) Genetic variation for Maternal effects on parasite resistance. Journal of Evolutionary Biology
Smith, PH., Mwangi, J.M., Afrane, Y.A., Yan, G., Obbard, D.J., Ranford-Cartwright, L.C. and T.J. Little. 2011 Alternative Splicing of the Anopheles gambiae Dscam Gene in Diverse Plasmodium falciparum Infections. Malaria Journal 10:156
Decaestecker, E., Labbé, P., Ellegaard, K., Allen, J. E., and T.J. Little. 2011. Candidate immune gene expression in the ecological functional genomics model Daphnia. Developmental and Comparative Immunology 35:1068-1077
Vale, P.F. Alex Best, A., Boots, M. and T.J. Little. 2011. Epidemiological, evolutionary and coevolutionary implications of context-dependent parasitism. American Naturalist. 177, 510-21
... Press Release for the above
Graham, A.L., Shuker, D.M., Pollitt, L., Auld, S., Wilson, A. and T.J. Little. Fitness consequences of immune responses: strengthening the empirical framework for ecoimmunology. Functional Ecology 25: 5-17
Obbard, D.J., Jiggins, F.M., Bradshaw, N.J. and T J. Little. 2011. Recent and recurrent selective sweeps of the antiviral RNAi gene Argonaute-2 in three species of Drosophila. Molecular Biology and Evolution 28: 1043-1056
2010
Allen, D.E. and T.J. Little. 2010. Dissecting the effect of a heterogeneous environment on the interaction between host and parasite fitness traits. Evolutionary Ecology 24: 499-508
Labbé, P., Vale, P, and T. J Little. Successfully resisting a pathogen is rarely costly in Daphnia magna. BMC Evolutionary Biology 10: 355
Allen, D.E. and T.J. Little. 2010. Identifying energy constraints to parasite resistance. Journal of Evolutionary Biology 24: 224-229
Little, TJ. Shuker, D.M., Colegrave, N., Day, T., and A.L. Graham. 2010. The coevolution of virulence: tolerance in perspective. PLoS Pathogens 6: e1001006
Auld, S.K.J.R., Scholefeld, J.A. and T.J. Little. 2010. Genetic variation in the cellular response of Daphnia magna (Cladocera:Crustacea) to its bacterial parasite. Proceedings of the Royal Society B 277: 3291-3297
Vale, P and T.J. Little. 2010. CRISPR-mediated phage resistance and the ghost of coevolution past. Proceedings of the Royal Society B 277: 2097-2103
2009
Labbe, P., MacTaggart, S.J. and T.J. Little. 2009. An ancient immunity gene duplication in Daphnia magna: RNA expression and sequence analysis of two Nitric Oxide Synthase genes. Developmental and Comparative Immunology 33: 1000-1010
Obbard, D.J.O., Welch, J.J. and Tom J Little. 2009. Inferring selection in the Anopheles gambiae species complex: an example from immune-related serine protease inhibitors. Malaria Journal 8:117
Vale, P and T.J. Little. 2009. Measuring parasite fitness under genetic and thermal variation. Heredity 103: 102-109
Duncan, A.B., Hall, S. and T.J. Little. 2009. Parasitism and environmental sex determination in Daphnia. Evolutionary Ecology Research 11: 965-973
Lazarro, BP, Little TJ (2009) Immunity in a variable world. Philosophical Transactions of the Royal Society 364: 15-26
Haag, C.R., McTaggart, S.J., Anaïs Didier, A., Little, T.J. and D. Charlesworth (2009) Nucleotide Polymorphism and Within-Gene Recombination in Daphnia magna and Daphnia pulex, Two Cyclical Parthenogens. Genetics 182: 313-323
McTaggart. S.J., Conlon, C., Colbourne, J.K., Blaxter, M.L. and T. J. Little (2009) The components of the Daphnia pulex immune system as revealed by complete genome sequencing. BMC Genomics 10: 17
Labbe, P. and T.J. Little (2009) Prophenoloxidase in Daphnia magna: cDNA sequencing and expression in relation to resistance to parasitism. Developmental and Comparative Immunology 33: 674-680
Allen, D.E. and T.J. Little. 2009. The molecular landscape of host-parasite coevolution. Cold Spring Harbor Symposia on Quantitative Bilogy LXXIV
2008
Little, T. J., Perutz, M., Crossan, C, Palmer, M., and V. A. Braithwaite (2008) Male Sticklebacks Make Antibiotic Nests: A Novel Form Of Parental Protection? Journal of Fish Biology 73:2380-2389
Nelson, L., Anderson, S., Archibald, A., Rhind, S., Condie, A., McIntyre, N., Thompson, J., Whitelaw, B., Little, T.J. and T. Hupp (2008) An animal model to evaluate the function and regulation of the adaptively evolving stress protein SEP53 in oesophageal bile damage responses. Cell Stress and Chaperones 13:375-385
Afrane, Y.A., Little, T.J., Lawson, B.W., Githeko, A.K. and G Yan (2008) Deforestation and Vectorial Capacity of Anopheles gambiae Giles Mosquitoes in Malaria Transmission, Kenya. Emerging Infectious Diseases 14: DOI: 10.3201/ eid1410.070781
Obbard, D.J., Callister, D.M., Jiggins, F.M., Soares, D., Yan, G and T. J. Little (2008) The evolution of TEP1, an exceptionally polymorphic immunity gene in Anopheles gambiae. BMC Evolutionary Biology 8:274
Brites, D., McTaggart, S., Krystalynne Morris, K., Anderson, J., Thomas, K. Colson, I. Fabbro, T., Little, T.J., Ebert,, D. and L. Du Pasquier (2008) The Dscam homologue of the crustacean Daphnia is diversified by alternative splicing like in insects. Molecular Biology and Evolution 25: 1429-1439
Vale, PF, Stjernman, M, Little, TJ (2008). Temperature dependent costs of parasitism and the maintenance of polymorphism under genotype by environment interactions. Journal of Evolutionary Biology. doi:10.1111/j.1420-9101.2008.01555.x
Little TJ, Colegrave N, Sadd BM, Schmid-Hempel P. (2008) Studying immunity at the whole organism level. Bioessays 30:404-5.
The above was a reply to: Hauton and Smith (2008) Bioessays 29(11) 1138-1146
And they furthered the discussion: Hauton and Smith (2008) Bioessays 30(4) 406
Little TJ (2008) Book review. Evolutionary Ecology of Parasites. Second Edition. By Robert Poulin. Princeton (New Jersey): Princeton University Press. The Quarterly Review of Biology, March 2008, vol. 83, no. 1.
Killick SC, Obbard DJ, West SA, Little TJ (2008). Parasitism and breeding system variation in North American populations of Daphnia pulex. Ecological Research 23:235-240. DOI 10.1007/s11284-007-0368-x
2007
Little TJ, Chadwick W, Watt K (2007). Parasite variation and the evolution of virulence in a Daphnia-microparasite system. Parasitology doi:10.1017/S0031182007003939
Little TJ, Nelson L, Hupp T (2007) Adaptive Evolution of a Stress Response Protein. PLoS ONE 2(10): e1003. doi:10.1371/journal.pone.0001003
Little, TJ and Killick, SC (2007). Evidence for a cost of immunity when the crustacean Daphnia magna is exposed to the bacterial pathogen Pasteuria ramosa. Journal of Animal Ecology (2007) 76, 1202-1207. doi: 10.1111/j.1365-2656.2007.01290.x
Obbard DJ, Linton Y-M, Jiggins FM, Yan G, Little TJ (2007). Population genetics of Plasmodium resistance genes in Anopheles gambiae: no evidence for strong selection. Molecular ecology. doi:10.1111/j.1365-294X.2007.03395.x
Little, T. J., Birch, J., Vale, P. and M. Tseng (2007) Parasite transgenerational effects on infection. Evolutionary Ecology Research 9(3):459-469.
Duncan, A.B. and Tom J. Little (2007) Parasite-driven genetic change in a natural population of Daphnia. Evolution 61 (4), 796–803. doi:10.1111/j.1558-5646.2007.00072.x
Guinnee, M, Gardner, A, Howard, A, West, S.A. and T.J. Little (2007) The causes and consequences of variation in offspring size: a case study using Daphnia. Journal of Evolutionary Biology doi:10.1111/j.1420-9101.2006.01253.x
2006
Wedekind C, Walker M, Little TJ. 2006. The separate and combined effects of MHC genotype, parasite clone, and host gender on the course of malaria in mice. BMC Genet. 2006 Nov 21;7(1):55
Killick. S.C., Carlsson, A.M., West, S.A., and T.J. Little. 2006. Testing the Pluralist Approach to sex: the influence of environment on synergistic interactions between mutation load and parasitism in Daphnia magna. The Journal of Evolutionary Biology 19: 1603-1611
Jensen, K.N., Little, T.J., Skorping, A., and D. Ebert. 2006. Empirical support for an optimal virulence in a castrating parasite. PloS Biology 4 e197 DOI: 10.1371
Obbard, D.J., Jiggins, F.M., and T.J. Little. 2006. Rapid Evolution of antiviral RNAi genes. Current Biology 16: 580-585.
Duncan, A., Mitchell S.E. and T.J. Little. 2006. Parasite-mediated selection in Daphnia: the role of sex and diapause. The Journal of Evolutionary Biology 19: 1183-1189
Little, T.J., Watt, K. and D. Ebert. 2006. Parasite-host specificity: experimental studies on the basis of parasite adaptation. Evolution 60: 31-38.
2005
Little, T. J. 2005. Genetic diversity and polyploidy in the cosmopolitan asexual ostracod Cypris pubera. Journal of Plankton Research 27: 1287-1293.
Little, T.J. and Neville Cobbe. 2005. Molecular evolution of immune-related genes from disease-carrying mosquitoes in the genus Anopeheles. Insect Molecular Biology 14:599-605.
Little, T.J., Hultmark, D. and A.F. Read. 2005. Invertebrate immunity and the limits of mechanistic immunology. Nature Immunology 6: 651-654.
Wedekind, C., Walker, M., and T.J. Little. 2005 The course of malaria in mice: MHC effects, but no general MHC heterozygote advantage in single-strain infections Genetics 170: 1427-130.
Chadwick, W., and T.J. Little. 2005. A parasite-mediated life-history shift in Daphnia magna. Proceedings of the Royal Society of London B 272: 505-509.
Mitchell, S.E., Rogers, E., Little, T.J. and A.F. Read. 2005. Host-parasite and genotype by environment interactions: Temperature modifies the potential for selection by a sterilising pathogen. Evolution 59:70-80
2004
Wedekind, C. and T.J. Little. 2004. The clearance of hidden cestode infection triggered by an independent activation of host defense in a teleost fish. The Journal of Parasitology 90: 1329-1331.
Little, T.J., Colbourne, J.K. & T.J. Crease. 2004. Molecular evolution of Daphnia immunity genes: polymorphism in a Gram Negative Binding Protein and an Alpha-2-Macroglobulin. Journal of Molecular Evolution: 59:498-506.
Ebert,, D., Carius, H. J., Little, T.J. and Decaestecker, E. 2004 The evolution of virulence, host castration and gigantism in a bacteria-Daphnia system. American Naturalist 164: s19-s32.
Mitchell, S., Read, A.F. and T.J. Little. 2004. The effect of a pathogen epidemic on the susceptibility to infection, reproductive investment and genetic structure of the cyclical parthenogen Daphnia magna. Ecology Letters 7: 848-858.
Guinnee, M, West, S.A. and T.J. Little. 2004. Testing small integer clutch-size models using Daphnia. American Naturalist 163:880-887.
Little, T.J. & A. R. Kraaijeveld. 2004. The ecological and evolutionary implications of immunological priming in invertebrates. Trends in Ecology and Evolution 19: 58-60.
2003
Little, T.J., O'Connor, B., Colegrave, N., Watt, K. and A.F. Read. 2003. Maternal transfer of strain-specific immunity in an invertebrate. Current Biology 13: 489-492.
2002
Little, T.J., Carius, H.J., Sakwinska, O. and D. Ebert. 2002. Competitiveness and life-history characteristics of Daphnia with respect to susceptibility to a parasite. The Journal of Evolutionary Biology15:796-802.
Little, T. J. 2002. The evolutionary significance of parasitism: do parasite-driven genetic dynamics occur ex silico? The Journal of Evolutionary Biology 15: 1-9.
2001
Little, T.J. and D. Ebert. 2001. Temporal patterns of infectivity in a Daphnia-microparasite system. Evolution 55: 1146-1152
Carius, H-J, Little, T.J., and D. Ebert. 2001. The potential for frequency-dependent selection and coevolution in a Daphnia-microparasite system. Evolution 55: 1136-1145
2000
Little, T.J. and D. Ebert. 2000. The cause of parasitic infection in natural populations of Daphnia(Crustacea: Cladocera): the role of host genetics. Proceedings of the Royal Society of London B 267:2037-2042.
Little, T.J. and D. Ebert. 2000. Sex, linkage disequilibrium, and patterns of parasitism in natural populations of Daphnia. Heredity 85: 257-265.
1999
Little, T.J. and D. Ebert. 1999. Associations between parasitism and host genotype in natural populations of Daphnia (Crustacea: Cladocera). Journal of Animal Ecology 68: 134-149.
Pre 1999
Little, T.J., DeMelo, R., Taylor, D.J. and P.D.N. Hebert. 1997. Genetic characterization of an arctic zooplankter: insights into geographic polyploidy. Proceedings of the Royal Society of London B 264: 1363-70.
Little, T.J. and P.D.N. Hebert. 1997. Clonal Diversity in high arctic ostracodes. Journal of Evolutionary Biology 10: 233-252.
Crease, T.J. and T.J. Little. 1997. Partial sequence of the mitochondrial genome of the crustacean Daphnia pulex. Current Genetics 31: 48-54.
Little, T.J. and P. D. N. Hebert. 1996. Endemism & ecological islands: the ostracodes from Jamaican bromeliads. Freshwater Biology 36: 327-337.
Little, T.J. and P.D.N. Hebert. 1994. Abundant asexuality in tropical freshwater ostracodes. Heredity 73: 549-555.
Book Chapters and comments
Little, T.J. and D. Ebert. 2004. Evolutionary dynamics of Daphnia and their microparasites in Evolutionary Aspects of Infectious Disease, Edited by K. R. Dronamraju. Cambridge University Press.
Little, T.J. 2005. Natural variation in immune system genes and how this might impact engineering issues in Christophe Boete (editor), Malaria Control with Genetically-Modified Mosquitoes. Landes Biosciences, Rotterdam.
Carpenter J.A., Jiggins, F.M. and T.J. Little. 2008. Dialogue on defenses: Report from the workshop on “the impact of the environment on innate immunity: At the defence frontier”, 22–27 April 2007. Developmental & Comparative Immunology 32: 307-309
Little, T.J. and P.D.N. Hebert. 1996. Ancient asexuals: scandal or artefact? Trends in Ecology and Evolution 11:296

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